MAPT and Cognitive impairment: Since this paradigm of doxycycline treatment rescues cognitive defects in Tg mice [51], these patterns suggest that we identified genes that mediate tau-driven cognitive impairment (Pattern 1), are not involved in cognitive rescue (Pattern 2), or that could be affected by doxycycline treatment paradigms (35d) used in this and other TET-dependent studies (Pattern 3).