MSH2 and cancer: To investigate the personal and family history of cancer in individuals with Lynch syndrome in the database, users can filter by ‘Classification: Pathogenic or Likely Pathogenic’ and ‘Gene: MLH1, MSH2, PMS2, MSH6, or EPCAM’ (https://data.color.com/v1/#classification=Likely%20Pathogenic&classification=Pathogenic&gene=MSH6&gene=MLH1&gene=MSH2&gene=PMS2&gene=EPCAM); individuals with Lynch syndrome accounted for 0.55% of the database population (Figure 4A).