BRCA1 and breast cancer: For example, 60.13% of the ‘Gene: BRCA1 or BRCA2’ subpopulation had breast cancer before age 50 years, with a mean onset age at 46.80 ± 11.87 years (Figure 2E) compared to 64% of the ‘Gene: PALB2’ subpopulation that had breast cancer before age 50 years, with a mean onset age at 49.20 ± 8.50 years (Figure 2F).