CD4 and viral infectious disease: It is surprising that no signal for miR-BHRF1-2 was found in the PI group because this miRNA (together with miR-BHRF1-3, miR-BART1, -2, -10-, and -22) cooperatively co-inhibits production of the IL-12-family cytokines responsible for the differentiation of CD4+ T-cells, which play a crucial role in the defence against the first stage of viral infections and are therefore a primary target of EBV immediately after B-cell infection [40].