The pattern of change in other hallmarks of hypertrophic cardiomyopathy (e.g. Anp, Bnp mRNA) and cardiac fibrotic markers (e.g. Collagen 1a1 and Collagen 3a1 mRNA) was comparable between Sirt5 KO and WT mice at 5 weeks after TAC (Fig 4G–4J). This evidence concerns the gene NPPA and hypertrophic cardiomyopathy.