SIRT5 and persistent truncus arteriosus: Accordingly, left ventricular end-diastolic volume (LVEDV) and left ventricular end-systolic volume (LVESV) were markedly reduced by 16.4% (P<0.05) and 36% (P<0.05), respectively, in Sirt5 KO mice compared to WT controls after TAC surgery (Fig 5C and 5D).