NLRP3 and Alzheimer disease: Amyloid-β (Aβ)-induced activation of TLRs and the NLRP3 (NACHT, LRR, and PYD domain-containing protein 3) inflammasome results in production and release of proinflammatory cytokines like IL-1β and genetic deletion of NLRP3 protects against Aβ pathology and cognitive dysfunction in AD mouse models (Heneka et al. 2013).