TLR2 and Dectin-1, both upregulated in human AD tissues (Webster et al. 2009; Friedman et al. 2018) and AD mouse models (Wes et al. 2014; Holtman et al. 2015), have been recognized as pattern recognition receptors for zymosan and separate reports have implicated BTK as an essential downstream component of both TLR2 and Dectin-1 signaling pathways in macrophages (Horwood et al. 2006; Strijbis et al. 2013). This evidence concerns the gene BTK and Alzheimer disease.