Furthermore, the dysfunction of the TCA cycle in CFS patients reported by (Yamano et al. 2016), inhibition of glycolysis and reduced levels of pyruvate reported by (Armstrong et al. 2015) and inactivated AMPK together with subnormal levels of IL-6 in the striated muscles of CFS patients reported by (Brown et al. 2015) are all abnormalities consistent with a pattern of metabolic downregulation associated with the cellular hibernation associated with endotoxin tolerance. Here, IL6 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.