NR3C1 and myalgic encephalomeyelitis/chronic fatigue syndrome: The work of (Vangeel et al. 2015, 2018) is also of interest as the pattern of hypomethylation of the glucocorticoid receptor gene NR3C1 1F region suggests an activated hypothalamic-pituitary-adrenal (HPA) axis in an attempt to counter peripheral inflammation rather than a blunted HPA response reported in people diagnosed with CFS according to wider criteria (reviewed (Morris et al. 2017a)).