Herein, to establish the NAFLD model in rats, we used the high-fat diet to administrate rats for 12 weeks, through detection the levels of liver functional enzyme (ALT, AST, TG and TC), antioxidant (SOD, GSH), peroxide products (MDA), the inflammation factors of TNF-α, IL-6, IL-8, and LDL-R mRNA levels to evaluated the possible beneficial effects and the possible action mechanism of Cs ethanol extract on NAFLD in rats. Here, CXCL8 is linked to metabolic dysfunction-associated steatotic liver disease.