LDLR and familial hypercholesterolemia: 2017). Liver expression of the LDL-R is a major factor in regulation of plasma levels of LDL cholesterol (LDL-C) (Ivaturi et al. 2014). Human patients with loss-of-function LDL-R could develop to familial hypercholesterolemia (Usifo et al. 2012), and the homozygous familial hypercholesterolemia patients could develop to advanced atherosclerotic lesions at an early age (López et al. 2018; Tada et al. 2018). Thus, LDL-R could cause the metabolism outlet of all kinds of lipoprotein, and regulate the content of plasma lipoprotein (Go 2015; Toldo et al. 2017).