TMBIM4 and neurodegenerative disease: The superior efficacy of a lower pridopidine dose (0.3 mg/kg) compared to a larger one (1.0 mg/kg) is in keeping with results obtained using potent S1R agonists both in 6-OHDA-lesioned mice [17] and other mouse models of neurodegenerative disease [5, 10, 56].