The expression of CD38, deletion of 13q14, and predominant nodal disease are associated with an increased risk of CLL progression [11]. Richter’s syndrome can be associated with a marked elevation of lactate dehydrogenase (LDH) level, rapidly enlarged lymph nodes, and fever in the absence of infection [4]. Our patient did not show any clinical symptoms of Richter’s syndrome. Here, CD38 is linked to B-cell chronic lymphocytic leukemia.