It was noticeable that CSMD1 was reported to be an important oncosuppressor in many tumors including melanoma (Tang et al., 2012), breast cancer (Kamal et al., 2010), head and neck cancer (Scholnick & Richter, 2003), and colorectal adenocarcinomas (Farrell et al., 2008). This evidence concerns the gene CSMD1 and head and neck cancer.