Several solute carrier family 22 members including SLC22A1, SLC22A3, and SLC22A7 were shown to be under-expressed in HCC and their down-regulation was associated with the poor prognosis of HCC patients (Heise et al., 2012; Schaeffeler et al., 2011; Yasui et al., 2014). The gene discussed is SLC22A3; the disease is hepatocellular carcinoma.