TNFRSF1A and TNF receptor 1-associated periodic fever syndrome: Indeed, in 1999, mutations in theTNFRSF1A gene, encoding TNFR1, were found to be associated with episodic fevers and profound localised inflammation; consequently, TNFR1-associated periodic syndrome (TRAPS) was defined as one of the disease entities under the collective heading of autoinflammatory diseases115.