Therefore, TNFR2 might be considered a potential novel therapeutic target for immunomodulation, not only in thrombocytopenia but also in other unrelated immune disorders associated with decreased levels of Treg cells, such as RA, AS, systemic lupus erythematosus (SLE), IBD, and psoriasis72. The gene discussed is TNFRSF1B; the disease is systemic lupus erythematosus.