Besides, genes procollagen-lysine, 2-oxoglutarate 5-dioxygenase2 (PLOD2) and collagen type I α1 chain (COL1A1) and tissue inhibitor of metalloproteinases 1 (TIMP1) are shown upregulating in osteoarthritis-related fibrosis; they are usually considered to be fibrogenic markers [5]. Here, TIMP1 is linked to osteoarthritis.