It is possible that HBOT leads to the decreased level of CRP, FFA, and cytokines, and consequently this leads to decreased activation of ERK1/2 and Akt activation and thus decreases the activity of NFκB, and subsequently iNOS or NFκB activation by cytokines in T1DM is achieved only through Akt. The gene discussed is NOS2; the disease is type 1 diabetes mellitus.