It is possible that HBOT leads to the decreased level of CRP, FFA, and cytokines, and consequently this leads to decreased activation of ERK1/2 and Akt activation and thus decreases the activity of NFκB, and subsequently iNOS or NFκB activation by cytokines in T1DM is achieved only through Akt. Here, AKT1 is linked to type 1 diabetes mellitus.