In male depression CASP6 was a strong predictor for state (AUC 87%, p = 0.00007, surviving Bonferroni correction for the 65 biomarkers tested), in male PTSD LY9 was a strong predictor for trait first year ED visits (AUC 77%, p = 0.041), and in male PTSD MFAP3 was a strong predictor for trait all future ED visits (OR 15.93, p = 0.00085). This evidence concerns the gene CASP6 and major depressive disorder.