Personalized by gender and diagnosis, in female bipolar CDK6 was a strong predictor for state (AUC 100%, p = 0.007), in female PTSD SHMT1 was a strong predictor for trait first year ED visits (AUC 100%, p = 0.022), and in female depression GNG7 for trait all future ED visits (OR 14.54, p = 0.022). This evidence concerns the gene CDK6 and major depressive disorder.