AIMP1 and microcephaly: The VARS phenotype is also similar to AIMP1 related disorders (MIM# 603605) which present with microcephaly, cortical cerebral atrophy and early-onset seizures but can be differentiated from VARS based upon presence of hypomyelinating leukodystrophy, similar to that of X-linked Pelizaeus–Merzbacher disease41,42.