We found that upregulation of VEGFA resulted in a significantly increase of cell proliferation, migration, invasion, and HUVECs tube formation, while HMGA2 overexpression could substantially counteract the effects of upregulation of miR-1249 on the migratory and invasive ability of CRC cells (Fig. 6b, c and S5A, 6D and S5B, 6E and S5C, 6F and S5D). This evidence concerns the gene VEGFA and colorectal carcinoma.