AKT1 and familial pancreatic carcinoma: Several studies have shown that Akt/mTOR signaling pathway played a key role in varieties of biological processes of cancers, such as proliferation, metastasis and angiogenesis, for example, miR-92b-3p/Gabra3 axis has been reported to modify pancreatic cancer cell growth and metastasis via regulating Akt/mTOR signaling pathway32.