Previous studies have been reported that VEGFA could bind to vascular endothelial growth factor receptor 2(VEGFR2), and then activate PI3K and its downstream target Akt and mTOR which play crucial roles in tumor growth, metastasis, angiogenesis and induce the epithelial–mesenchymal transition (EMT)16–18. This evidence concerns the gene AKT1 and neoplasm.