The sh-LINC01234, sh-SHMT2 and miR-642a-5p groups showed significantly smaller tumors than the group treated with the scrambled sequence, indicating that LINC01234 and SHMT2 promoted tumor growth, and miR-642a-5p suppressed tumor growth (Fig. 8b, c, *P < 0.05). Here, SHMT2 is linked to neoplasm.