As shown in Fig. 5a, LINC01234 and SHMT2 share 2 common significantly downregulated microRNAs (miR-625–5p and miR-642a-5p) in colon cancer, and these microRNAs can directly target LINC01234 and SHMT2. The gene discussed is SHMT2; the disease is malignant colon neoplasm.