SHMT2 and malignant colon neoplasm: To further validate whether LINC01234 and SHMT2 were in the same axis, SHMT2-overexpressed plasmid was transfected into colon cancer cells with LINC01234 knocked down, revealing that SHMT2 overexpression reversed the effect of LINC01234 silencing on the decreased cell proliferation and activity of the serine/glycine biosynthetic pathway (Fig. 4d, e), suggesting that LINC01234 promotes cell proliferation, at least in part, through promoting SHMT2 expression.