ETV2 and myocardial infarction: In addition to the direct effects of ETV2 on angiogenesis, recent studies have demonstrated the role of ETV2 in direct conversion of non-ECs (i.e., fibroblasts and skeletal muscle) into EC-like cells, suggesting the possibility that some proportion of newly formed vessels in MI hearts originated from non-ECs through direct conversion upon lentiviral ETV2 injection28,39–41.