Unfortunately, examining whether live HCMV can subsequently inhibit responses triggered by UV-HCMV is complicated by the fact that UV-HCMV represents an exceptionally potent stimulus of IRF3- and IFN-mediated antiviral innate responses, rendering cells highly refractory to normal HCMV infection (28, 29, 69). The gene discussed is IFNA1; the disease is cytomegalovirus infection.