Given the established importance of dsDNA-reactive PRR pathways to terminate in IFN activation (IFN-terminal) in response to HCMV infection (37, –, 40) and the ability of cytoplasmic dsDNA, as well as other herpesviral PAMPs, to activate the inflammasome (9, 10, 50, 51), we decided to explore this using the promonocytic human cell line THP-1. Here, IFNA1 is linked to cytomegalovirus infection.