Disease causing mutations in TDP-43, FUS, hnRNP A1, hnRNP A2B1, MATR3 and TIA1 all point to disturbed function of RNA binding proteins, especially hnRNPs, as playing a role in the pathogenesis of FTD and ALS [46]. The gene discussed is MATR3; the disease is amyotrophic lateral sclerosis.