CD8A and neoplasm: Our finding of anti-PD-1 blockade efficacy in TDLN also fits with a recent report from Chamoto and colleagues who showed in a mouse model that antitumor efficacy of PD-1 blockade depended on continuous recruitment of effector-memory CD8+ T cells, which were induced to proliferate by PD-1 inhibition [46], from TDLN to tumor sites.