CD274 and cancer: Many clinical trials have shown that releasing immunosuppressive brakes on effector T cells, e.g. by blocking inhibitory receptors such as cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death (−ligand)-1 (PD-(L)1), leads to unprecedented complete and long-lasting clinical responses in subgroups of patients with various cancer types [8–10].