ANGPT2 and acute respiratory distress syndrome: They reported that KL-6, lactate dehydrogenase (LDH), SRAGE, von Willebrand factor (vWF), and IL-8 displayed the highest effect size for ARDS diagnosis, and interleukin-4 (IL-4), IL-2, Angiopoietin-2 (Ang-2), and KL-6 had the highest effect size for ARDS prognosis (assessed by pooled odds ratio).