Synthetic–lethal relationships exist for ATPases, BRG1 and BRM, in triple negative breast cancer, for accessory subunits of the SWI/SNF complex, ARID1A and ARID1B, in colorectal cancer and CHD1 with transcriptional regulator PTEN in prostate cancer [75–77]. The gene discussed is SMARCA2; the disease is prostate carcinoma.