DRAM1 and non-small cell lung carcinoma: Given that of the cell lines tested, DRAM2 showed the lowest expression in H661 where endogenous p53 expression was more than 20 times higher than that of other cell lines (Fig. 2c), and the fact that DRAM2 shares significant homology with DRAM, which can act either p53 dependently [26] or independently [27], it was necessary to explore the relationship between DRAM2 and p53 in NSCLC.