DRAM2 and non-small cell lung carcinoma: Next, we sought to determine whether the expression of DRAM2 could affect cell proliferation of NSCLC, thus, cell cycle analysis, MTT assay, and colony formation were performed in A549 and SK cells after either overexpressing or downregulating DRAM2, and the differences in results for each assay were statistically significant (Fig. 4a-c).