The PI3K/Akt signaling pathway is a crucial pathway involved in the regulation of the proliferation and survival of tumor cells in various types of malignancies, including DLBCL [38].The PI3K/Akt pathway is highly activated in DLBCL and induces a survival advantage, increasing the metastatic ability and drug-resistance [39]. The gene discussed is AKT1; the disease is neoplasm.