TP53 and non-Hodgkin lymphoma: In previous studies, we demonstrated that irradiated or rituximab-treated NHL cells (k1106 cells or SU-DHL-4 cells) induce Foxp3+ Treg and Th17 cells to secrete IL-17 by increasing the secretion of IL-6; the secreted IL-17 then inhibits the irradiation-induced apoptosis of NHL cells by suppressing p53 [17–19].