PMAIP1 and neuroblastoma: In our NB cell lines, a significant correlation (r2 = 0.59, p = 0.026) was demonstrated between IC50 and PRIMA-1MET-induced Noxa expression, suggesting that together with mitochondrial dysfunction (Additional file 2: Data for Figure S2), Noxa could play a role in PRIMA-1MET-induced NB apoptosis.