After adjusting for age, BMI, hypertension, diabetes, smoking, triglycerides, total cholesterol, low-density lipoprotein, homocysteine, EPCs, SDF-1, and VEGF, multivariate logistic regression analysis showed that age, hypertension, diabetes, EPCs, and SDF-1 are independent risk factors for HR-NICE. The gene discussed is CXCL12; the disease is diabetes mellitus.