For example, mutations of Homo sapiens TBC1D23 make it unable to exert its inhibitory effect on innate immunity signaling in spatiotemporal fashion, which contribute to a variety of diseases including sepsis, Crohn’s disease, atherosclerosis and cancer [7], and a TBC1D20 mutation is associated with Warburg Micro syndrome 4 (WARBM4), an autosomal recessive disorder characterized by congenital eye, brain, and genital abnormalities [8]. The gene discussed is TBC1D20; the disease is Crohn disease.