Li et al. reported that metformin could attenuate melanoma cell growth and metastasis through suppressing Tribbles homolog 3 (TRIB3) expression and Lysine acetyltransferase 8 (KAT8)-mediated Spinal muscular atrophy (SMA)-and Mothers decapentaplegic (MAD)-related protein 3 (SMAD3) acetylation [24]. Here, KAT8 is linked to melanoma.