Our identification of the regulation of PGF by ORAI3 during hypoxia was somewhat surprising, given reports that in MDA-MB-231 basal breast cancer cells, hypoxic induction of PGF is HIF-dependent [65]; however, PGF induction by hypoxia in this investigation was suppressed by simultaneous silencing of both HIF1α and HIF2α and hence this is an area for further study. This evidence concerns the gene HIF1A and breast carcinoma.