Despite the increases in hypoxia-induced ORAI3 expression in MDA-MB-468 ERα-negative breast cancer cells, this up-regulation of ORAI3 did not bestow an ability to contribute to SOCE, which is apparent in ERα-positive MCF-7 breast cancer cells where ORAI3 silencing suppresses SOCE [28,29]. Here, ESR1 is linked to breast cancer.