PGF and breast carcinoma: Our identification of the regulation of PGF by ORAI3 during hypoxia was somewhat surprising, given reports that in MDA-MB-231 basal breast cancer cells, hypoxic induction of PGF is HIF-dependent [65]; however, PGF induction by hypoxia in this investigation was suppressed by simultaneous silencing of both HIF1α and HIF2α and hence this is an area for further study.