Although ORAI1 silencing studies have indicated that ORAI1 is a contributor to the proliferation and invasiveness of both basal and non-basal breast cancer cells in vitro, reports of increased ORAI1 mRNA levels in basal compared to non-basal breast cancers suggested that ORAI1 may make a greater contribution to these functions in breast cancer subtypes [11]. Here, ORAI1 is linked to breast carcinoma.