Although the NXNL1 gene does not contain risk alleles for age-related macular degeneration (AMD), the fact that the NXNL1 gene encodes for two protein products that protect the cones at the center of the macula whose function is ultimately defective in AMD could suggest that the NXNL1 gene is involved in AMD pathophysiology. Here, NXNL1 is linked to age-related macular degeneration.