High levels of APOE expression are observed in subretinal mononuclear phagocytes of AMD patients [60], CX3C chemokine receptor 1 (CX3CR1)-deficient mice60, and humanized transgenic mice expressing the human AMD risk APOE2-allele (TRE2 mice) [60,61,109]. The gene discussed is CX3CR1; the disease is age-related macular degeneration.