The depletion of INSR in both WAT and brown AT (BAT) in mice, obtained through the Cre-recombinase/aP2 system (FIRKO), resulted in an impairment of insulin-mediated glucose transport and suppression of lipolysis, reduced fat mass without insulin resistance or glucose intolerance and extended lifespan [82,106]. The gene discussed is INSR; the disease is Insulin resistance.