Some heterogeneity in E-cadherin expression has been previously described in pancreatic adenocarcinoma [31,39] as well as in PCa, showing variable E-cadherin expression in metastatic tissues compared to primary tumor tissues [15,16,17,18,19,20], thus increasing the relevance of studies aimed at characterizing the phenotype of PCa cells in relation to the expression of EMT markers, and especially of E-cadherin, in order to better understand PCa development and progression. This evidence concerns the gene CDH1 and neoplasm.