Since, oncogenes such as Myc may up-regulate tumor development not only through their fundamental influence on cell proliferation but also via their control of immune checkpoints that enables evasion from immune surveillance [34], it will be interesting to validate whether Myc can regulate the expression of the immune checkpoint gene products in NK cells, as well as if other oncogenes, which are known to modulate Myc, can regulate immune checkpoints in NK cells. The gene discussed is MYC; the disease is neoplasm.