Despite the antitumor efficacy demonstrated by the mTOR inhibitors (rapalogs) rapamycin and everolimus in murine models of Pca [90,224,225], the performances of rapalogs in phase I and II clinical trials were not so satisfactory, leading to application of second generation mTOR inhibitors or further combination therapies in Pca [226,227,228,229]. The gene discussed is MTOR; the disease is posterior cortical atrophy.