Moreover, mTORC1 also regulates some other proteins such as hypoxia-inducible factor 1α (HIF-1α), protein phosphatase 2A (PP2A), glycogen synthase, and signal transducer and activator of transcription (STAT) 3, through which mTORC1 promotes biosynthesis of proteins, lipids and nucleotides in aberrant cells, tissue and organism growth in cancer [2,50,51,52,53,54]. The gene discussed is HIF1A; the disease is cancer.