Studies in PCa cell lines indicated that the PI3K/Akt/mTOR pathway contributed to PCa radioresistance (RR) through mechanisms of intrinsic radioresistance, cancer cell proliferation and hypoxia, and in those PCa RR cell lines, the PI3K/Akt/mTOR pathway was the most active [221,222]. Here, PIK3CD is linked to posterior cortical atrophy.