Considering the importance of the MAP kinase pathway [16] and the PI 3-kinase pathway [9] for cancer cell proliferation, a Mek inhibitor, AZD-6244 [24], and a PI 3-kinase inhibitor, AZD-6482 (http://lincs.hms.harvard.edu/kinomescan/), were also included in the current study. This evidence concerns the gene MAP2K7 and cancer.