A high TAK1 signature very clearly separated high-ADAM12 from low-ADAM12 tumors both in lung (Supplementary Figure S7D) and colon (Supplementary Figure S7G), and the TAK1 activation score was positively correlated with ADAM12 expression, and negatively correlated with KAT2A expression, in both tumor types (Supplementary Figures S7H–I). The gene discussed is KAT2A; the disease is neoplasm.