Previous whole genome and exome sequencing studies have reveled recurrently mutated genes (such as NOTCH1, MYD88, TP53, ATM, SF3B1, FBXW7, POT1, CHD2, RPS15, IKZF3, ZNF292, ZMYM3, ARID1A, and PTPN11), but deletions of chromosome 13q14 is the most frequent aberration in CLL, occurring in 55% of cases [82]. Here, NOTCH1 is linked to B-cell chronic lymphocytic leukemia.