FUS and amyotrophic lateral sclerosis: Indeed, ALS-linked mutations in FUS have been suggested to affect diverse functions, including gain and loss of RNA processing (Sun et al., 2015; Reber et al., 2016), deregulation of SMN function (Sun et al., 2015; Yamazaki et al., 2012; Groen et al., 2013; Tsuiji et al., 2013), biogenesis of circular RNA (Errichelli et al., 2017), DNA damage response (Qiu et al., 2014; Wang et al., 2013), axonal transport (Groen et al., 2013; Guo et al., 2017), activity-dependent translation (Sephton et al., 2014), and intra axonal protein synthesis (López-Erauskin et al., 2018).