The let‐7 family of microRNAs, which are also expressed by NSCs, have been shown to protect against neuroinflammation by regulating the expression of caspase 3, inducible nitric oxide synthase (iNOS), TNF‐α, and IL‐12, which improve stroke‐induced neurological deficits in mice (Akerblom et al., 2012; Banerjee et al., 2013; Ni et al., 2015). This evidence concerns the gene NOS2 and Stroke.