The compound set tested against human neuroblastoma (SHSY5Y) and rat liver cell lysates for TrxR inhibition using DTNB assay revealed a promising inhibitory profile for 6 out 16 compounds tested, namely, higher inhibitory potency toward hepatocyte lysate TrxR1 compared to SHSY5Y lysate. This evidence concerns the gene TXNRD1 and neuroblastoma.