DDIT3 and diabetes mellitus: These findings provide novel insights into the crucial direct role of gly‐HDL and the crosstalk between ER stress and autophagy in diabetes‐associated atherosclerotic pathogenesis, suggesting that enhanced autophagy is a beneficial adaptive response that alleviates the excessive activation of ER stress‐CHOP pathway and suppresses gly‐HDL‐induced macrophage apoptosis.