In this study, we perform integrated analysis including differently expressed genes, gene ontology (GO) analysis, KEGG pathway analysis, survival analysis both to identify a panel of key candidate genes involved in colon cancer, and we found that SPP1, VIP, COL11A1, CA2, ADAM12, and INHBA could provide great significant prognostic value for colon cancer. This evidence concerns the gene SPP1 and malignant colon neoplasm.