As the majority of these predicted mutations were found to be rare in the general population used in ExAC (although nearly all of the most highly prevalent amino acid substitution alleles were present; see Tables 2 and 3), these data argue for possible pathophysiological actions for RGMA and RGMB in human neoplasms, and represent another illustration in which focused analysis of information extracted from large‐scale databases can help identify new areas of investigation with possible biomedical consequences. The gene discussed is RGMA; the disease is neoplasm.