Another surprising observation with regard to RGMA and RGMB is their expression in a range of different cancers, with transcripts encoding mutant proteins being detected in up to 10% of cases of prostate cancer (RGMB) and in 3.5% of ovarian carcinomas (RGMA, see Results), again providing evidence for their unexplored roles in human disease. The gene discussed is RGMA; the disease is cancer.