Some previous studies demonstrated that several hnRNP family members changed significantly in BMSCs during osteogenesis and can regulate gene transcription and RNA splicing in bone metabolism.35, 36 The change of hnRNPL expression after drug treatment in osteosarcoma cells indicates that hnRNPL was involved in the physiological activity of bone‐related cells,37 and the alternative splicing mediated by hnRNPL is associated with protein phosphorylation.38 We therefore investigated the expression and effect of hnRNPL in PDLCs during the osteogenic differentiation with Sr stimulation. Here, HNRNPL is linked to osteosarcoma.