However, Tg‐APP/PS1 mice exposed to moderate hyperoxygenation (mHO2; 42% O2, 2 ATA), starting from 7 months of age, for 1 hr daily for 2 weeks or more, in a manner similar to the treatment with 100% O2 at 2 ATA (Supporting information Figure S6a), showed the same cognitive deficits in the water maze test (Supporting information Figure S6b–f) and novel object recognition test (Supporting information Figure S6g–i), as the Tg‐APP/PS1 control mice. This evidence concerns the gene APP and Cognitive impairment.