Similar with our results, celastrol can induce the activation of JNK and inactivation of AKT in multiple myeloma cells RPMI-8226 (33), activation of p38 in ovarian cancer cells OVCAR-8 and colorectal cancer cells SW620 cells (34) and inactivation of ERK in hepatoma cells Hep3B (35). Here, MAPK8 is linked to hepatocellular carcinoma.