HIF1A and cancer: Previously, the role of HIF-1α, MDR1 and LAPTM4B had been individually studied in different cancers at tissue levels and provide directional evidence regarding the engagement of these genes in tumor expansion, metastasis and therapy resistance(Gottesman, Fojo & Bates, 2002; Gruber et al., 2004; Holzmayer et al., 1992; Li et al., 2010).