In spite of a number of genetic loci identified by linkage studies in schizophrenia,1 only a few genes have been mapped in these loci, such as PRODH (SCZD4) (Jacquet et al., 2002), DISC1 (SCZD9) (Debono et al., 2012, 1), SHANK3 (SCZD15) (Gauthier et al., 2010), NRXN1 (SCZD17) (Rujescu et al., 2009), and SLC1A1 (SCZD18) (Myles-Worsley et al., 2013, 1). The gene discussed is SHANK3; the disease is schizophrenia.