In the context of this work, the loss of adaptation occurs in the expression of PD-1 receptors on anti-melanoma CD8+ T cells, a phenomenon that may constitute the essence of the previously unrecognized immunologic factor (1), while competing push-pull factors (3) correspond to opposite outcomes of the corresponding kinetic motifs identified as incoherent feedforward loops (IFFLs) in the classification of Alon (6). The gene discussed is CD8A; the disease is melanoma.